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Radiologic tests[ edit ] A small bowel follow-through may suggest the diagnosis of Crohn's disease and is useful when the disease involves only the small intestine. The granulomas of Crohn's disease do not show "caseation", a cheese-like appearance on microscopic examination characteristic of granulomas associated with infections, such as tuberculosis.
Erythrocyte sedimentation rate ESR and C-reactive protein help assess the degree of inflammation, which is important as ferritin can also be raised in inflammation. Biopsies may also show chronic mucosal damage, as evidenced by blunting of the intestinal villi , atypical branching of the crypts, and a change in the tissue type metaplasia. Finding a patchy distribution of disease, with involvement of the colon or ileum, but not the rectum , is suggestive of Crohn's disease, as are other endoscopic stigmata.
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